Press Releases

Neo-Advent Technologies Awarded FDA-Sponsored Research Grant “Critical Process Parameters for the Preparation of Amphotericin B Liposomes”

Littleton, MA, Oct. 1, 2016—Neo-Advent Technologies, LLC (NAT) of Littleton, MA, has been awarded a U.S. FDA research grant to evaluate “Critical Process Parameters for the Preparation of Amphotericin B Liposomes.” The objectives of this study are to determine the critical manufacturing process parameters of the liposomal drug amphotericin B using Quality by Design (QBD), as well as to develop and verify analytical methods to test product bioequivalence. The FDA hopes that with this study it will glean the information necessary to assess not only the new wave of Amphotericin B generics that will be shortly hitting the market, but also have the tools to evaluate other new liposomal drug platforms. This research project will strengthen the FDA’s knowledge when advising stakeholders and ANDA sponsors of liposomal products.

CEO Nelson Landrau says, “Neo-Advent Technologies is honored to receive this contract. The methodologies being developed will serve as an important tool for the FDA in evaluating future arrivals of generic liposomal products of amphotericin B, as well as other liposomal drug platforms.”

COO Alex Nivorozhkin adds, “This contract focuses on the full manufacturing schematics and comprehensive panel of related analytical methods for one of the most sophisticated and least understood drug formulation types in the market place. The methodology to be developed in this project will serve as an important tool to support future arrivals of new bioequivalent liposomal products of amphotericin B. We hope that such products will be potent and safe, and will maintain critical importance and superiority in the management of severe fungal infections across the globe.”

Neo-Advent Technologies was founded in 2003 to develop cutting-edge technologies in pharmaceutical and material science.

For more information, contact Nelson Landrau at:

Neo-Advent Technologies
410 Great Road, Suite 6-2-13
Littleton, MA 01460
(508) 970-4858

NAT is Key Contractor on Fourth Grant for Reactive Innovations

BOSTON, November 8, 2007—Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC from the National Science Foundation. The goal is to formulate, design, and produce thin film flexible barrier coatings specifically for flexible OLEDs (FOLEDs).

One of the biggest advantages of OLEDs over other display technologies is the ability to fabricate them on flexible substrates, mainly because of the efficient, emissive, solid-state nature of the devices and the absence of viewing angle effects. Flexible substrates, including plastics, have several advantages over glass: ruggedness, robustness, ultra-low weight, conformability, and impact resistance. However, use of FOLEDs is hampered by limited lifetime exhibited by these displays. This is due to the ingress of water and oxygen into the device.

The project will be focused on the formulation, design and fabrication of a thin flexible film barrier coating for FOLEDs. The goal is a coating with outstanding barrier properties that can be applied with standard (non physical/chemical vapor deposition) coating processes. A commercialization partner, Universal Display Corporation, will assist the project by advising on FOLED coating requirements and evaluating barrier coated substrates with the goal of incorporating the barrier coating into their products.

NAT is Key Contractor on Third Grant for Reactive Innovations

BOSTON, May 31, 2007—Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC from the Centers for Disease Control The goal will be to develop a new line of scratch resistant, self-cleaning, anti-fog eyewear to protect citrus crop workers.

The US Department of Health and Human Services, in cooperation with the Partnership for Citrus Worker Health, has identified an urgent need for improved protective eyewear for citrus workers. Studies of serious occupational eye injuries have demonstrated that safety glasses would prevent the majority of injuries, if used. However, worker acceptance is low, primarily because current safety eyewear is poorly suited for harvesting citrus in hot, humid conditions because the lenses do not provide the required combination of scratch resistance, self-cleaning capability, and anti-fog characteristics.

Neo-Advent Technologies, LLC with its teaming partners Reactive Innovations, LLC and Bacou-Dalloz Eye & Face Protection Inc., will formulate, design, and fabricate a scratch resistant, anti-fog/self-cleaning coating to address this issue. The new coating will combine the flexibility and adhesion of a polymer with the hardness and chemical resistance of glass.

Potential commercial applications include Rx lens manufacturers, food-packaging developers, and suppliers of automotive glass for windshields and mirrors. The Rx lens market represents more than $3 billion in sales each year. This improved coating technology could revolutionize the transparent substrate marketplace.

NAT is Key Contractor on Second Grant for Reactive Innovations

BOSTON, May 1, 2006—Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC (RIL) by the Department of Energy to develop a new barrier coating for advanced photovoltaic modules.

The Department of Energy is interested in improving renewable energy technologies such as photovoltaics to allow them to reach their full potential. A critical need for photovoltaic module packaging is the development of barrier coatings to protect solar cells from water and water vapor. Not only must these coatings be impermeable to water vapor, but they must also be optically transparent, stable at high temperatures, unaffected by UV radiation, chemically resistant, and easy to apply, giving a low cost. Furthermore, coating adhesion to commonly used polymeric encapsulants and backsheets, such as ethylene vinyl acetate (EVA) and polyvinylflouride (PVF), must be excellent. It is highly desirable to have one material and application technique that would work for all types of solar cells.

Neo-Advent Technologies (NAT) and its partners Reactive Innovations, LLC (RIL) and Madico are formulating, designing, and fabricating a photovoltaic device barrier coating (PDBC) for use in renewable energy applications. To accomplish this, the team is developing a new technology by synthesizing novel materials and using them in a unique configuration. This technology will enable a photovoltaic module barrier coating that can be applied without the use of physical/chemical vapor deposition (PVD/CVD) processes.

NAT is inventing the chemical formulations of the barrier coating; RIL is designing a system that exhibits exceptional barrier properties while maintaining flexibility and ease of application; Madico is assisting in evaluating the samples and scaling the technology for commercialization.

The outcome of this barrier coating process will provide the government and industry with a coating system that meets or exceeds the performance of presently used coatings and their corresponding pretreatments/primers. The present focus of this technology is toward PV devices/modules, although it has a broad scope of applications where outdoor weather protection and barrier coating protection are required. Some of the areas where this technology can be successfully adopted include aircraft, ships, electronics, aerospace, automotive, construction, and scratch resistant coatings. Specifically, these markets include food/beverage packaging and barrier technologies for organic light emitting devices.

NAT is Key Contractor on Grant for Reactive Innovations

BOSTON, February 16, 2006—Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC (RIL) by the US Navy to develop a radar-absorbing and non-skid coating for marine flight decks. Currently available flight deck coating systems used under normal temperature fluctuations with heavy traffic usage have poor performance in the areas of reduced radar signature return. The Navy requires that new coatings be developed that maintain a high coefficient of friction and excellent adhesion to the decking. Simultaneous with these requirements, the coatings must also absorb radar using radar-absorbing materials over the advanced new destroyer, DD(X), design frequencies. Typical of current non-skid coating systems, new coatings with radar absorbing materials must be resistant to sunlight/UV, seawater, and shipboard chemicals while demonstrating excellent wear, impact, and corrosion resistance.

Neo-Advent Technologies and Reactive Innovations, LLC are working in conjunction with R&F Products, who will synthesize coatings using a combination of novel components and processing techniques. The first phase of NAT's development contract will demonstrate the feasibility of fabricating non-skid and radar absorbing coatings, with later phases finalizing the coating formulation to military specification MIL-PRF-24667B by working with the US Navy, the DD(X) prime contractor, and a commercialization partner, ITW American Safety Technologies.

Beyond military applications, there are a number of applications where a non-skid and radar-absorbing coating is needed. Areas where this technology can be successfully adopted include building construction materials such as electromagnetic wave absorption panels and the communications industry that require minimal signal reflection in communication tower platforms.