Instrumentation

NAT uses state-of-the-art instrumentation in the areas of chromatography, spectroscopy, microscopy, and drug and polymer testing.

Separation

  • Analytical (Agilent 1100, 1200) and Preparative (Varian Dynamax) High Performance Liquid Chromatography (HPLC)
  • Varian Load&Lock columns with packing station
  • Separation Detection Systems
    • Spectrophotometric (UV-Vis)
    • Fluorescence
    • Evaporative Light Scattering (ELSD)
    • Electrospray Ionization-Ion Trap Mass Spectrometry (ESI-IT-MS)
    • Atmospheric Pressure Chemical Ionization-Ion Trap Mass Spectrometry (APCI-IT-
    • MS)

Mass Spectroscopy

  • Quadrupole/linear ion trap (MDS SCIEX 4000 QTRAP)

Molecular Spectroscopy

  • Ultraviolet-Visible Spectrophotometry (UV-Vis)
  • Fourier Transform Infrared Spectroscopy, FT-IR (Nicolet Spectrum 100)

Atomic Spectroscopy

  • Flame Atomic Absorption (FAA)

Microscopy and Surface Analysis

  • Optical Microscopy
  • Heated Table Polarized Light Optical Microscopy

Physical and Thermal Testing

  • Thermogravimetric Analysis, TGA (TA Instrument Q500TGA)
  • Differential Scanning Calorimetry, DSC (TA Instrument Q1000)
  • Particle Size Analysis (Malvern, Mastersizer)

Wet Chemical Techniques and Other Equipment

  • Karl Fischer Volumetric Titration
  • pH
  • Ion Selective Electrodes (ISE)
  • Soxhlet Extraction
  • Accelerated Solvent Extraction
  • Brookfield Viscometers
  • Weathering Chambers (Temperature, Humidity Control)

Drug Formulation

  • Tablet Press
  • Carver Press (Heated Plates)
  • Film Casting Table
  • Homogenizer (Polytron 10/35)
  • Osmomolality
  • Tablet Hardness
  • Tablet Friability
  • Tap Density
  • Flow Density
  • Dissolution (Distek 2100)
  • Lyophilization (VirTis Genesis)
  • Microfluidizer (Microfluidics, M-110S)
  • Lipex Extruder (100 mL)