Neo-Advent Technologies LLC is a pre-clinical contract research organization offering a full spectrum of CMC services for drug development. Our core competencies include drug formulation and analysis.
NAT operates a full state-of-the-art solid dose facility that supports accelerated development of tablet dose forms and coated formulations. Our capabilities range from feasibility studies to production scale batches. We provide comprehensive services in analysis, due diligence, and the design of IP strategies that will enable the launch of programs focused on new drug delivery technologies and drug reformulations.
We provide expertise in drug formulation, from concept design to cGMP technology transfer, including solid and liquid dose forms, topical, ocular, and parenteral compositions.
NAT can help you micronize your API using either wet or dry micronization techniques. We offer streamlined micronization approaches that are uniquely suited for early-stage pre-clinical development. These programs are designed to rapidly develop processes to micronize your API for increased solubility and bioavailability. This program features unparalleled speed for rapidly delivering products for use in formulations and in vivo studies.
Drug Delivery Technologies
NAT has expertise in specialized areas of drug delivery and controlled release, including:
- sol-gel nano-encapsulation
- smart hydrogels and biomaterials
- electrorheologically-controlled drug release
- compositions based on polyphosphazene polymers
Our analytical and bioanalytical services span from HPLC method development to thermal analysis (TGA, DSC), and particle size analysis to metabolite characterization and profiling by LC/MS. We conduct a full range of GLP stability studies, and we thoroughly analyze polymers and raw ingredients using our extensive Instrumentation Suite.
NAT operates a fully equipped synthetic scale-up laboratory (5-50L reactors, Load&Lock purification columns) and can carry out work in optimization of synthetic drug candidates, intermediates, and polymer building blocks. We also offer a selection of chiral amino acids, biopolymers, polymer building blocks (monomers for high performance polymers), polyphosphazene polymers, porphyrins, and other custom items from our catalog of chemical reagents and materials.
We offer a variety of services in toxicology and pharmacology to assist in preclinical and clinical development of pharmaceuticals and medical devices. Our services include:
- evaluation of in-licensing and out-licensing opportunities
- safety assessment of small molecules and biopharmaceuticals
- drug metabolism and pharmacokinetics
- biocompatibility analysis for medical devices
We can design comprehensive regulatory strategies for preclinical and early clinical development and provide assistance in interactions with the FDA in preparing IND filing.
NAT can produce high performance coatings based on hybrid organic and inorganic components. These materials are designed for use as scratch-resistant, weather-resistant, and UV-resistant topcoats for plastics. We can also synthesize and test a variety of materials for medical and commercial applications.